Regardless of its molecular mechanisms of action(s), increased levels of MMP11 expression is reported to modulate cell survival [92]–[96], to act as a negative prognostic of cancer patient survival [97]–[99], and to promote oncogenic homing, tumorigenesis and metastasis [92], [96], cardinal manifestations triggered also by haploinsufficiency and hypomorphism of Ranbp2[48]. Here, RANBP2 is linked to cancer.