A recent national Internet survey on thrombolysis for acute ischemic stroke showed that physicians in emergency departments were reluctant to use t-PA.7 As many as 40% would not administer intravenous recombinant rt-PA for acute ischemic stroke, even under ideal conditions, largely because of the risk of symptomatic intracerebral hemorrhage. The gene discussed is PLAT; the disease is intracerebral hemorrhage.