CSF2 and lung disorder: Histoplasma capsulatum is a dimorphic fungus that develops a yeast-like morphology in host tissue that leads to the development of pulmonary disease characterized by chronic granulomatous and suppurative inflammatory reactions [1, 2] and the increased expression of cytokines, including interleukin- (IL-) 12, interferon- (IFN-) γ, tumor necrosis factor- (TNF-) α, granulocyte macrophage colony-stimulating factor (GM-CSF), IL-17, and IL-23, which are critical for the immunoprotective response in H. capsulatum-infected mice [3–7].