GBA1 and Mental deterioration: A previous report of 3 patients with GBA mutations who underwent STN-DBS also identified a more aggressive process that led to both cognitive impairment and axial impairments23; whereas, of 2 other patients with GBA mutations who underwent STN-DBS, 1 had early cognitive decline, and the second had persistent benefit.9 Whether there is an interaction between GBA status and the risk of subsequent cognitive decline after STN-DBS needs to be clarified.