Since increased invasion (Cheng et al, 2011) and therapy resistance (Bao et al, 2006; Chen et al, 2012) have been observed in cancer stem cells (Venere et al, 2011), and ZEB1 is a known regulator of stemness and SOX2 in other solid tissue cancers (Wellner et al, 2009), we hypothesised that ZEB1 has similar functions in glioblastoma. This evidence concerns the gene SOX2 and cancer.