Since increased invasion (Cheng et al, 2011) and therapy resistance (Bao et al, 2006; Chen et al, 2012) have been observed in cancer stem cells (Venere et al, 2011), and ZEB1 is a known regulator of stemness and SOX2 in other solid tissue cancers (Wellner et al, 2009), we hypothesised that ZEB1 has similar functions in glioblastoma. The gene discussed is SOX2; the disease is glioblastoma.