TFR2 and hereditary hemochromatosis: The genes presented in the table include HFE, HFE2, HAMP, TFR2, ACO1, FTL, NEO1, TFRC, FPN1, HEPH and TF. Approximately 80 % of hereditary hemochromatosis (HH) is explained by mutations in the HFE gene (or Type 1 HH), but other genes including HFE2, HAMP, TFR2 and FPN-related genes are all involved in non-HFE HH through their direct or indirect regulation of hepcidin, an iron-regulating hormone in the liver [115, 116].