Gene expression analysis demonstrated that, compared to mice in the C group, mice in the TB group exhibited an upregulated expression of uncoupling protein 3 (UCP3; p=0.03), forkhead box O 3α (FOXO3α; p=0.04) and atrogin-1 (p=0.0084), as well as an upregulated expression of pyruvate dehydrogenase kinase 4 (PDK4; p=0.01), an inhibitor of the pyruvate dehydrogenase complex. The gene discussed is PDK4; the disease is tuberculosis.