The mechanisms that lead to NAFLD development vary and are associated with an unbalance of several cellular processes related to the signaling pathways of insulin, including the increased flow of FFA to the liver (lipolysis), the de novo lipogenesis of FFA, decreased beta-oxidation, mitochondrial dysfunction, oxidative stress, and endoplasmic reticulum stress [32]. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.