Abundances of microglia with much larger round- or amoeboid-shape cell bodies were observed in the brain sections of two sCJDs, but only a few Iba1 positive-stained cells with small cell body were detected in the tested two kinds of inherited prion diseases showing similar patterns as normal one (Figure 3), even in the brains of G114V gCJD which contained lager amounts PrPSc deposits. The gene discussed is AIF1; the disease is prion disease.