There were frequent grade 3 to 4 hematologic toxicities (76.3% for leukopenia and 84.2% for neutropenia) in this study, much higher than our previous study using L-asparaginase, vincristine plus dexamethasone in relapsed or refractory cases[10], in which 2.2% of cases experienced grade 3 to 4 leukopenia. Here, ASPG is linked to Decreased total neutrophil count.