MTAP and nodular malignant melanoma: In this region the associated variants and the 187 tagged variants were located in intergenic region telomeric to MTAP gene or intronic to MTAP gene; only one variant was located in exon 3 of MTAP. Interestingly a study reported that the MTAP variant rs10757257 was associated with increased risk of superficial spreading/nodular melanoma but not with lentigo malignant melanoma that is the subtype associated with chronic sun exposure.