COPS5 and nasopharyngeal carcinoma: Genetic alterations have been reported in NPC, and our recent findings showed that one such alteration, c-Jun activation domain-binding protein-1/constitutive photomorphogenic-9 signalosome (Jab1/CSN5), which negatively regulates p27, is overexpressed in this disease [7] and thus contributes to NPC resistance to radiotherapy and chemotherapy [8,9].