Of note, these studies about the enhancement of graft-versus-tumor effects and the reduction of GVHD by means of combined DLI/trAb application was thoroughly performed upon administration of C57 splenocytes with or without pretreatment of anti-EpCAM x anti-CD3 trAb BiLu in (BALB x C57BL/6) F1 H-2d/b mice that were previously inoculated with a lethal dose of B16-EpCAM melanoma cells. This evidence concerns the gene EPCAM and melanoma.