In addition, Riechelmann and co-workers showed that opsonization of autologous effector cells (i.e. peripheral blood mononuclear cells) with anti-EpCAM x anti-CD3 trAb catumaxomab led to beneficial results (i.e. tolerability, safety and response) in patients with intractable recurrent head and neck squamous cell carcinomas [27]. The gene discussed is EPCAM; the disease is head and neck squamous cell carcinoma.