Activation of the VEGF-C/VEGFR-3 axis in lymphatic ECs promotes lymph node metastasis, while binding of VEGF-C to VEGFR-3 creates a positive-feedback ‘autocrine loop’ which further enhances VEGF-C release, to dramatically stimulate cancer cell proliferation as well as lymphangiogenesis [26]. The gene discussed is FLT4; the disease is cancer.