Rapamycin significantly decreased intratumoral lymphatic vascular density from 9.1 ± 4.10 in control mice to 5.8 ± 1.18 in rapamycin-treated mice (p = 0.027) as well as the fraction of lymphatic vessels (identified by LYVE-1 staining) invaded by tumor cells in primary OSC-19 tumors obtained from mouse lingual tissue (Figure 1D). The gene discussed is LYVE1; the disease is neoplasm.