LAMB2 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: Although in the dystroglycanopathies currently known it is more common to observe a reduction of some specific O-Man (important for laminin binding) rather than of O-GalNAc (typical of the mucin-like portion) glycans, it is not unreasonable to foresee still unidentified cases of dystroglycanopathy in which a scenario would emerge of a significantly reduced level of glycosylation and consequent destabilization of the hypoglycosylated α-DG molecule.