CSF2 and Alzheimer disease: In this condition, the airborne proteins produced by HDM, such as cysteine and serine proteases, have direct proteolytic activity on the skin that contribute to barrier impairment and delayed barrier recovery in patients with AD [29], by disrupting epithelial tight junctions, by inducing degranulation of eosinophils, and by activating keratinocytes, that leads to increased production of interleukin (IL)-6, IL-8, and granulocyte-macrophage colony-stimulating factor (GM-CSF) [30,31].