Compared to the reference group, TB patients 45 years old or more (HR = 2.58, 95% CI: 1.34-4.92), patients with ambulatory and bedridden functional status (HR = 2.76, 95% CI: 1.71-4.47 and HR = 3.88, 95% CI: 2.15-7.02 respectively), and patients with CD4 count less than 75 cells/μl (HR = 2.08, 95% CI: 1.17- 3.70) had an increased risk of mortality during TB treatment. This evidence concerns the gene CD4 and tuberculosis.