A similar epithelial to mesenchymal transition process might occur in our experimental setting, accompanied by Twist and Snail-mediated repression of E-cadherin.33 Alternatively, phosphatidylinositol 3 kinase/AKT signaling could directly act on focal adhesion kinase.34 Focal adhesion kinase and Src are known to modulate E-cadherin and thereby promote cancer cell invasion.35 Further addition of an AKT inhibitor reversed the invasive phenotype similarly to the combined inhibition of EGFR and Met (Figures 2a, 5c and 5d). The gene discussed is TWIST1; the disease is cancer.