Invasive growth of tumor cells on stimulation with EGF or HGF is well known.25 Although a variety of studies on the cross-talk of the two receptors and their inhibition have been published,19, 21, 26 it has not been previously described that addition of EGFR inhibitors to HGF-stimulated cells can increase invasiveness in comparison with growth factor treatment only. The gene discussed is HGF; the disease is neoplasm.