In CD, examples include CYP1B1 that has been marked as an inflammatory bowel disease marker compared to healthy controls in peripheral blood gene expression profiles [4]; RNASE2 was significantly reduced in patients with inflammatory bowel disease compared to healthy controls in peripheral polymorphonuclear leukocytes[22],as was FCGR1A, an inflammation-related gene thatis up-regulated in PBMCs of patients withulcerative colitis and CD [23]. This evidence concerns the gene RNASE2 and inflammatory bowel disease.