To test this hypothesis, we investigated in the current study, the expression of telomerase (TERT), some tumour suppressor gene (Rb, E2F3, TP53 and CDKN1A (p21)) as well as some proto-oncogenes (FGFR3) that influence pathogenesis of BC in HCV infected patients and compare their expressions with those in the non-HCV infected patients. The gene discussed is TP53; the disease is breast cancer.