The immunoreactivity was 42% (21/50) for TP53, 26% (13/50) for CDKN1A (p21) and 76% (38/50) for FGFR3 in malignant bladder tissues of non-infected patients, while the immunoreactivity was 84% (42/50) for TP53, 6% (3/50) for CDKN1A (p21) and 96% (48/50) for FGFR3 in bladder tumors associated of HCV-infected patients (p< 0.001). This evidence concerns the gene TP53 and urinary bladder neoplasm.