HMGB1 and Sepsis: Here, 3 days of treatment with the anti-HMGB1 mAb 2G7 in sepsis survivors normalized splenocyte counts and numbers of circulating neutrophils, lymphocytes and monocytes, as well as the cytokine response to endotoxin, indicating that HMGB1 is necessary for the development of this immunophenotype in murine sepsis survivors.