Like their deacetylase counterparts, HAT activities are also modulated by phosphorylation, and, indeed, phosphorylation of TIP60 by a conserved serine/threonine kinase encoded by HSV-1, HCMV, EBV and KSHV has been shown to activate TIP60 during herpesvirus infection and to induce DNA damage responses and chromatin remodeling [116]. Here, TMPRSS11D is linked to Herpesviridae infectious disease.