In SPECT and SPECT/CT images of 123I-HSA-TIMP2 (Figure 4(A), left) and 123I-RGD-HSA-TIMP2 (Figure 4(A), right) for 4 h after injection, it was observed that 123IHSA-TIMP2 was not absorbed by the mice bearing U87MG xenografts, but the level of tumor uptake of 123I-HSA-RGD-TIMP2 was slightly higher. The gene discussed is TIMP2; the disease is neoplasm.