Nonetheless, further adjustment for adiponectin and inflammation markers led to additional large decreases – HR[obesity] from 2.7, 1.7–4.1 to 1.8, 1.2–2.9 and HR[waist circumference] from 3.6, 2.3–5.8 to 2.5, 1.6–4.1). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.