This study was designed to examine the specificity and efficacy of folate-nanoliposome entrapped MYCN siRNA in treatment of metastatic neuroblastoma, showing that MYCN siRNA was distributed specically in tumor tissues under the direction of folate-folate receptor interaction and further silences MYCN gene expression both in mRNA and protein levels and finally induces apoptosis of neuroblastoma cells. The gene discussed is MYCN; the disease is neuroblastoma.