In a study conducted in China that looked at CHEK2 mutations based on whole gene analysis, a novel recurrent missense mutation, p.H371Y, was identified in 5/118 (4.2%) familial and 16/909 (1.8%) unselected breast cancer patients and in 9/1,228 (0.7%) controls [37]. This evidence concerns the gene CHEK2 and breast carcinoma.