NOS3 and gestational diabetes: In another hand, it is now established that GDM are pathological conditions altering hCAT (cationic amino acid transporter-1)-mediated arginine transport and eNOS (endothelial nitric oxide synthase) synthesis of NO in human feto-placental vasculature, due to abnormal signaling pathway leading to altered vascular reactivity and changes in umbilical vessels blood flow from and to fetus with serious consequence on its growth [35].