Both hypergastrinemia and mutational activation of the CCK2 receptor have been linked to development of neuroendocrine gastrointestinal tumours (carcinoids) [7]; and gastrin and CCK2R are reported to be upregulated in human pancreatic adenocarcinoma [12,13]. The gene discussed is CCKBR; the disease is digestive system neuroendocrine tumor, grade 1/2.