Review evidence cited a study that occasional false negative results may be caused by: (i) deletion or mutation of the HRP-2 gene; (ii) anti-HRP-2 antibodies in humans may explain why some tests were negative despite significant parasitemia; and (iii) presence of an inhibitor in the patient’s blood preventing development of the control line [13]. The gene discussed is HDGFL2; the disease is parasitic infectious disease.