More ePK inhibitor-bound structures of APH have since been solved, including one of APH(2′′)-IVa bound with the wide-spectrum flavonol type inhibitor, quercetin (2) (Shakya et al., 2011), as well as a series of ePK inhibitor-bound structures APH(3′)-Ia solved by the Center for Structural Genomics of Infectious Diseases (PDB accession numbers 4GKH, 4GKI, 4FEU, 4FEV, 4FEW, 4FEX). The gene discussed is APEH; the disease is infectious disease.