CXCR3 and neoplasm: Only the latter combination improved significantly the survival of tumor-bearing mice through a mechanism based upon (i) ZOL-driven tumor infiltration with TCR Vδ2 cells which expressed the cytotoxic granule associated Tia-1 molecule, (ii) IFN-γ production by TCR Vδ2 cells which stimulated CXCL10 expression in tumor cells, (iii) inhibition of tumor angiogenesis operate by CXCL10 that may serve as chemoattractant for continuous recruitment of TCR Vδ2 cells expressing the specific receptor CXCR3 to the tumor site (Di Carlo et al., 2013) (Figure 3).