EGFR and colorectal cancer: Similar mathematical modeling has successfully predicted the dynamics of acquired resistance, including the timing of treatment failure, in colorectal cancer patients treated with the EGFR inhibitor panitumumab (Diaz et al., 2012), and has led to specific recommendations for combination therapies to treat CML (Komarova et al., 2009; Katouli and Komarova, 2010).