BRAF and melanoma: These include gefitinib and erlotinib for non-small-cell lung cancer patients with EGFR mutations (Sequist et al., 2008), panitumumab and cetuximab for metastatic colon cancer (Amado et al., 2008), vemurafenib for patients with melanomas harboring BRAF mutations (Chapman et al., 2011), and crizotinib for lung cancer patients with EML4-ALK translocations (Kwak et al., 2010).