To detect putative PRE/TRE in the human genome in silico, we selected genes that show altered expression in acute lymphoblastic leukemia (ALL) with t(4∶11) translocation, because the translocation partner MLL on chromosome 11 is a homeotic regulator that shares homology with Drosophila trithorax gene [41]. Here, KMT2A is linked to acute lymphoblastic leukemia.