The gene set we selected for analysis shows over or under expression in ALL patients with t(11∶4) translocation and detected a high density of YY1 binding motif in the first intron of PIK3C2B. The other recently identified, PRE-kr, that regulates expression of mouse MafB/Kreisler gene, D11.12, the region between HoxD11 and HOXD12 identified in human embryonic cells and PRE in FSHD also contain YY1 binding motif [29], [30], [31]. The gene discussed is HOXD12; the disease is acute lymphoblastic leukemia.