Similar to viruses and some other intracellular bacteria such as Salmonella and Listeria [7], a protective role of CD8+ T cell responses is supported by the murine TB model [8] and Mtb-specific CD8+ T cells are found in Mtb-infected humans and include both T cells classically restricted by HLA-Ia [9]–[12] and non-classically restricted by HLA-E [13] and MR1 [14]. Here, CD8A is linked to tuberculosis.