In the stratified analysis by ethnicity, ESR1 PvuII (C>T) is significantly correlated with increased risk of prostate cancer among Asian populations (T allele vs. C allele: OR = 1.28, 95%CI: 1.05–1.57, P = 0.015; TT + TC vs. CC: OR = 1.23, 95%CI: 1.01–1.49, P = 0.039; TT vs. CC + CT: OR = 1.59, 95%CI: 1.10–2.30; P = 0.016; TT vs. CC: OR = 1.77, 95%CI: 1.16–2.72, P = 0.009; TT vs. CT: OR = 1.49, 95%CI: 1.06–2.09, P = 0.023; respectively) (Figure 2). The gene discussed is ESR1; the disease is Familial prostate cancer.