When all the eligible studies were pooled into the meta-analysis, the results showed that ESR1 PvuII (C>T) and XbaI (A>G) polymorphisms were not associated with the risk of prostate cancer, yet many studies have inferred that ESR1 gene polymorphisms were related to the onset and develop of prostate cancer [11], [12], [26], [37], [41]–[43]. This evidence concerns the gene ESR1 and Familial prostate cancer.