SIRT1 and metastatic malignant neoplasm in the lymph nodes: In this study, down-regulation of SIRT1 is correlated with certain unfavorable prognostic factors including lymph node metastasis and late clinical (TNM) stage, indicating that SIRT1 may be involved in lymph node metastasis and the development of LSCCs and HSCCs, which seems to provide some valuable information for the judgement of prognosis and choice of therapies for clinicians.