Other rare colonic polyposis syndromes for which the genetic basis is known include Cowden syndrome (mutations in PTEN), juvenile polyposis (mutations in SMAD4 or BMPR1A), hereditary mixed polyposis syndrome (mutation in GREM1), and MUTYH-associated polyposis (biallelic mutations in MUTYH). Here, BMPR1A is linked to hereditary mixed polyposis syndrome.