CDKN2A and cancer: We also observed the significant correlation of p16 hypermethylation and OS in studies with REMARK score greater than 12 in NSCLC (HR 1.79, 1.35–2.39) and CRC (HR 1.96, 1.16–3.34), further confirming the prognostic role of p16 hypermethylation in these 2 cancer types (Figure 2A,C, and Table 1).