To test whether our classification could successfully predict new common fragile site gene genes, we examined whether induction of replicative stress in a colon cancer cell line can generate deletions in MACROD2 or A2BP1, which, together with the known common fragile site gene gene FHIT, are the three genes most frequently affected by focal deletions in colon cancer. The gene discussed is RBFOX1; the disease is malignant colon neoplasm.