In our previous study of MUC1, we examined the adhesion profiles of ZR-75-1 and MCF7 cells on combined surfaces of E-selectin and ICAM-1.14 We found that whereas both cell lines exhibited high levels of MUC1, only ZR-75-1 cells exhibited uMUC1 which leads to slower rolling velocities (facilitated by E-selectin) and the existence of firm adhesion events (facilitated by ICAM-1) which strongly suggested that the uMUC1 glycoprotein significantly participates in the adhesion of metastatic cancer cells to the inflamed endothelium. The gene discussed is ICAM1; the disease is metastatic malignant neoplasm.