IL1A and Alzheimer disease: MiR-146a is among the more extensively investigated miRNAs in AD: it is up-regulated in response to IL-1, Aβ42 and oxidative stress in cultured human neuronal glial cells (Lukiw et al., 2008; Cui et al., 2010; Holohan et al., 2012; Lukiw and Alexandrov, 2012).