CD8A and viral infectious disease: Thus, CD8+ T cells play an important role during viral infections (Miles et al., 2010), which typically elicit strong CD8+ T cell responses, many of which have been well-characterized, including those to HTLV-1 (Bieganowska et al., 1999; Vine et al., 2004), although some viruses can escape CD8+ T cell mediated clearance (Klenerman and Zinkernagel, 1998; Overbaugh and Bangham, 2001).