Instead, mice overexpressing human APP [APP-yeast artificial chromosome (APP-YAC mice), PDAPP, and recently 3xTg-AD mice] displaying Aβ plaque pathology were developed and studied using the CCI model (Murai et al., 1998; Nakagawa et al., 1999, 2000; Hartman et al., 2002; Uryu et al., 2002; Conte et al., 2004; Tran et al., 2011a, 2012) (Table 1). This evidence concerns the gene APP and Alzheimer disease.