MAPT and Alzheimer disease: Neuropathology is diagnostic and extracellular plaques of Aβ peptides and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau proteins are typically found in the brains of AD patients (Blennow et al., 2006; Trojanowski et al., 2010; Kennedy et al., 2012; Weiner et al., 2012).