Finally, AF could be induced by an intra-esophageal burst pacing protocol in mice harboring the RyR2-R2474S+/−, RyR2-N2386I+/−, and RyR2-L433P+/− mutations known to be associated with human CPVT. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.