RYR2 and catecholaminergic polymorphic ventricular tachycardia: Increased diastolic Ca2+ release has been implicated in generation of ventricular arrhythmias in genetically modified mouse models harboring CPVT-related RyR2 mutations (Cerrone et al., 2005; Kannankeril et al., 2006; Goddard et al., 2008; Lehnart et al., 2008; Suetomi et al., 2011).