RYR2 and catecholaminergic polymorphic ventricular tachycardia: This in turn results in spontaneous Ca2+ waves of Ca2+-induced Ca2+ release (CICR) in turn producing the delayed afterdepolarisation (DADs) thought to be the major cause of RyR2-associated CPVT (George et al., 2007; Mohamed et al., 2007; Priori and Chen, 2011).