The loss of stromal caveolin-1 (Cav-1) has been linked to a “reverse Warburg effect” (Warburg, 1956), resulting in autophagy and mitophagy in tumor-associated fibroblasts that provide additional energy-producing intermediates to tumor cells in the microenvironment that support tumor growth (Pavlides et al., 2009; Lisanti et al., 2010; Pavlides et al., 2010a,b,c) Moreover, low levels of stromal Cav-1 is a biomarker for poor prognosis in some common cancers, such as prostate cancer and breast cancer (Mercier et al., 2008; Di Vizio et al., 2009; Witkiewicz et al., 2009a). This evidence concerns the gene CAV1 and cancer.