For example, in human clinical trials, curcumin was shown to down-regulate NF-kB and STAT-3 and is thought to have potential for the prevention and/or treatment of pancreatic cancer, familial adenomatous polyposis (FAP), inflammatory bowel disease, durable bowel disease, and other pro-inflammatory diseases. This evidence concerns the gene NFKB1 and Familial adenomatous polyposis.