NFKB1 and cancer: Based on a large volume of research data, including the aforementioned and other studies, one may conclude that most gene products associated with inflammation can contribute to cancer development as well as progression; survival, proliferation, invasion, angiogenesis, and metastasis, all of which are regulated by NF-kB and STAT-3 (Rolland et al., 1980; Sheng et al., 2001; Pai et al., 2002; Chang et al., 2004).