Most agents that promote inflammation activate NF-kB, including endotoxins, carcinogens, radiation, chemotherapy, hyperglycemia, tumor promoters, inflammatory cytokines [e.g., tumor necrosis factor (TNF), interleukin 1 (IL-1)], and growth factors such as epidermal growth factor (EGF). Here, NFKB1 is linked to neoplasm.