Impaired NRG1 migration of B-lymphocytes isolated from patients with schizophrenia vs. controls has also been demonstrated that was associated with polymorphisms in NRG1 and the gene for catechol-o-methyl-transferase [COMT (Sei et al., 2007)], an enzyme required for degradation of neurotransmitters including dopamine and that has also been heavily implicated in schizophrenia via association studies (Williams et al., 2007). This evidence concerns the gene NRG1 and schizophrenia.