A role for the involvement of GSK3β signaling in schizophrenia has come from a number of studies including the demonstration that decreased AKT1 expression was present in the brain and lymphocytes of patients with schizophrenia (Emamian et al., 2004) that was recently replicated for lymphocytes at the gene expression level (van Beveren et al., 2012). The gene discussed is AKT1; the disease is schizophrenia.