Post-mortem studies have also reported reduced binding of the radioligand [3H]4-DAMP, under CHRM1/CHRM3/CHRM4/CHRM5 selective assay conditions, in the orbitofrontal cortex from subjects with Alzheimer's disease who had significant psychotic symptoms (Tsang et al., 2008). This evidence concerns the gene CHRM1 and Alzheimer disease.