In support of a glutamatergic dysfunction in schizophrenia, kainate receptor expression is decreased in the dlPFC in schizophrenia (Scarr et al., 2005), while hippocampal expression of the NR1 and NR2B subunits of the NMDA receptor are increased and decreased, respectively (Gao et al., 2000). This evidence concerns the gene GRIN2B and schizophrenia.