RIT2 couples stimulation by nerve growth factor to the p38 mitogen-activated protein kinase and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) signaling pathways that are required for neuronal differentiation of PC6 pheochromocytoma cells [9]; RIT2 promotes neurite outgrowth through activation of Rac/Cdc42 and association with calmodulin [10]. Here, BRAF is linked to hereditary pheochromocytoma-paraganglioma.