Regarding TCF7L2 rs7903146, localizedin an intronicregion of the gene, the most interesting findings were that the risk allele T and the genotype TT showed an increasing statistical significance, from modest genotypic association with the disease when all T2D patients (D) were compared with the age-matched controls (CTR) (OR=1.63; 95% CI 1.26-2.09) to intermediate values (OR=1.79; 95% CI 1.28-2.52) when T2D patients with complications (D+Co) were compared with CTR. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.