In BA9 of children with autism we observed significant increases in ratios for RAC1/β-actin (P <0.008, d = 2.74), RAC1/NSE (P <0.017, d = 2.09), APP 120 kDa/β-actin (P <0.032, d = 2.03), APP 120 kDa/NSE (P <0.017, d = 2.12), APP 88 kDa/β-actin (P <0.025, d = 2.54) and APP 88 kDa/NSE (P <0.012, d = 3.24) (Figures 1 and 4, Table 3). This evidence concerns the gene APP and autism.