Expression of HMGB1 in inflammatory cells of seborrheic keratosis, precancerous lesions, basal cell carcinoma and squamous cell carcinoma was significantly higher than in normal skin (P = 0.0024); HMGB1 expression in inflammatory cells of benign seborrheic keratosis increased non-signigicantly (Figure 1l). This evidence concerns the gene HMGB1 and squamous cell carcinoma.