In addition, p65 in epithelial nuclei was negatively correlated with HMGB1 in the epithelial intercellular spaces (r = -0.1641, P > 0.05; Figure 5e and 5g), and was negatively correlated with HMGB1 in the inflammatory cells in normal skin and various tumor types (r = -0.0452, P > 0.05; Figure 5f and 5g). This evidence concerns the gene HMGB1 and neoplasm.